понедельник, 22 июня 2015 г.

Drug combinations

Drug combinations


Drug combinations


WARNING! For educational purposes: We do not endorse any of these combinations. This page will always be 'work in progress'. It is extremely important to be safe at all times! See below the graphic for important information regarding specific combinations.


This chart is meant as a quick reference guide and additional research MUST always be done. If you use this chart or information on your site you must link to the full summaries and display this message.


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Low Risk & Synergy - These drugs work together to cause an effect greater than the sum of its parts, and they aren't likely to cause an adverse or undesirable reaction when used carefully. Additional research should always be done before combining drugs.


Low Risk & No Synergy - Effects are just additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.


Caution - These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.


Unsafe - There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.


Dangerous - These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.


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cannabis & lsd


Status: Caution


Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.


amphetamines & lsd


Status: Caution


Note: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences


cocaine & lsd


Status: Caution


Note: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences


tramadol & lsd


Status: Unsafe


Note: Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.


cannabis & mushrooms


Status: Caution


Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.


Status: Caution


Note: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences


cocaine & mushrooms


Status: Caution


Note: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences


Status: Unsafe


Note: Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.


cannabis & dmt


Status: Caution


Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.


amphetamines & dmt


Status: Caution


Note: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences


Status: Caution


Note: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences


tramadol & dmt


Status: Unsafe


Note: Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.


5-meo-xxt & mescaline


Status: Caution


Note: The 5-MeO class of tryptamines can be unpredictable in their interactions


Status: Caution


Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.


Status: Caution


Note: The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops


Status: Caution


Note: The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops


Status: Low Risk & No Synergy


Note: High doses of caffeine are uncomfortable and this will be magnified by psychedelics


Status: Unsafe


Note: This combination can cause seizures due to the lowering of the threshold by tramadol and the potential of mescaline to cause seziures.


Status: Caution


Note: The 5-MeO class of tryptamines can be unpredictable in their interactions, particularly increasing the risk of unpleasant physical side effects.


cannabis & dox


Status: Caution


Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.


ketamine & dox


Status: Low Risk & Synergy


Note: Ketamine and psychedelics tend to potentiate each other - go slowly.


Status: Caution


dxm & dox


Status: Unsafe


Note: The DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also potentiate DOx resulting in an unpleasantly intense experience.


pcp & dox


Status: Unsafe


Note: Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.


amphetamines & dox


Status: Unsafe


Note: The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenic.


mdma & dox


Status: Caution


Note: The combined stimulating effects of the two can be uncomfortable. Coming down on the MDMA while the DOx is still active can be quite anxiogenic.


cocaine & dox


Status: Unsafe


Note: The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought loops. Coming down from cocaine while the DOx is still active can be quite anxiogenic


caffeine & dox


Status: Caution


Note: High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating it may cause some physical discomfort.


alcohol & dox


Status: Low Risk & Decrease


Note: Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk.


opioids & dox


Status: Low Risk & No Synergy


Note: No unexpected interactions.


tramadol & dox


Status: Unsafe


Note: Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.


maois & dox


Status: Caution


5-meo-xxt & nbomes


Status: Caution


Note: The 5-MeO class of tryptamines can be unpredictable in their interactions and the NBOMes are known to be unpredictable even alone. This combination is best avoided


cannabis & nbomes


Status: Caution


Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.


mxe & nbomes


Status: Caution


amphetamines & nbomes


Status: Unsafe


Note: Amphetamines and NBOMes both provide considerable stimulation. When combined they can result in tachycardia, hypertension, vasoconstriction and in extreme cases heart failure. The anxiogenic and focusing effects of stimulants are also not good in combination with psychedelics as they can lead to unpleasant thought loops. NBOMes are known to cause seizures and stimulants can increase this risk.


cocaine & nbomes


Status: Unsafe


Note: Cocaine and NBOMes both provide considerable stimulation. When combined they can result in severe vasoconstriction, tachycardia, hypertension, and in extreme cases heart failure.


caffeine & nbomes


Status: Caution


Note: Caffiene can bring out the natural stimulation from psychedelic drugs to make it uncomfortable. High doses can cause anxiety which is hard to handle while tripping


tramadol & nbomes


Status: Unsafe


Note: Tramadol is well known to lower seizure threshold and NBOMes have also shown a tendency to cause severe seizures


maois & nbomes


Status: Caution


5-meo-xxt & 2c-x


Status: Caution


Note: The 5-MeO psychedelics can interact unpredictably to potentiate other psychedelics


cannabis & 2c-x


Status: Caution


Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.


Status: Caution


Note: The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally uneccessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.


cocaine & 2c-x


Status: Caution


Note: The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.


caffeine & 2c-x


Status: Low Risk & No Synergy


Note: High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.


tramadol & 2c-x


Status: Unsafe


Note: Tramadol is well known to lower seizure threshold and psychedelics raise the risk of seizures.


maois & 2c-x


Status: Caution


5-meo-xxt & 2c-t-x


Status: Caution


Note: Both classes of compounds can be unpredictable alone


cannabis & 2c-t-x


Status: Caution


Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.


amphetamines & 2c-t-x


Status: Unsafe


Note: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences. In extreme cases, they can result in severe vasoconstriction, tachycardia, hypertension, and in extreme cases heart failure.


cocaine & 2c-t-x


Status: Unsafe


Note: Cocaine and 2c-t-x both provide considerable stimulation. When combined they can result in severe vasoconstriction, tachycardia, hypertension, and in extreme cases heart failure.


caffeine & 2c-t-x


Status: Low Risk & No Synergy


Note: High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.


alcohol & 2c-t-x


Status: Low Risk & Decrease


Note: Both these classes of compound can interact unpredictably. Caution should be exercised.


opioids & 2c-t-x


Status: Low Risk & No Synergy


Note: No expected interactions, some opioids have serotonin action, and could lead to Serotonin Syndrome or a seizure. These are pretty much only to Pentazocine, Methadone, Tramadol, Tapenatdol.


maois & 2c-t-x


Status: Caution


Note: MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably, which could be dangerous given the unpredictability of the 2C-T-x series


cannabis & amt


Status: Caution


Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics. Small amounts can reduce nausea with aMT but take care.


caffeine & amt


Status: Caution


Note: High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.


alcohol & amt


Status: Caution


Note: aMT has a broad mechanism of action in the brain and so does alcohol so the combination can be unpredictable


opioids & amt


Status: Low Risk & No Synergy


Note: No unexpected interactions


maois & amt


Status: Dangerous


Note: aMT is an MAOI on its own. Using enzyme inhibitors can greatly reduce predictability of effects.


Status: Low Risk & Synergy


Note: Little information exists about this combination.


dxm & 5-meo-xxt


Status: Unsafe


Note: Little information exists about this combination.


cannabis & 5-meo-xxt


Status: Caution


Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.


amphetamines & 5-meo-xxt


Status: Unsafe


Note: The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.


mdma & 5-meo-xxt


Status: Caution


Note: Some of the 5-MeO tryptamines are a bit unpredictable and should be mixed with MDMA with care


cocaine & 5-meo-xxt


Status: Unsafe


Note: The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.


caffeine & 5-meo-xxt


Status: Low Risk & No Synergy


Note: High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.


amphetamines & cannabis


Status: Caution


Note: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences


mdma & cannabis


Status: Low Risk & Synergy


Note: Large amounts of cannabis may cause strong and somewhat unpredictable experiences in combination with MDMA. Cannabis should be saved for towards the end of the experience if possible.


cocaine & cannabis


Status: Caution


Note: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences


alcohol & cannabis


Status: Low Risk & Synergy


Note: In excess, this combination can cause nausea.


amphetamines & ketamine


Status: Caution


Note: No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.


mdma & ketamine


Status: Low Risk & Synergy


Note: No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.


cocaine & ketamine


Status: Caution


Note: No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.


caffeine & ketamine


Status: Low Risk & No Synergy


Note: No unexpected interactions.


alcohol & ketamine


Status: Dangerous


Note: Both substances cause ataxia and bring a very high risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.


ghb/gbl & ketamine


Status: Dangerous


Note: Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.


opioids & ketamine


Status: Dangerous


Note: Both substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.


benzodiazepines & ketamine


Status: Caution


Note: Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position.


maois & ketamine


Status: Caution


Note: MAO-B inhibitors appear to increase the potency of Ketamine. MAO-A inhbitors have some negative reports associated with the combination but there isn't much information available


Status: Caution


Note: There are no reports available about this combination


amphetamines & mxe


Status: Caution


Note: Risk of tachycardia, hypertension, and manic states


Status: Caution


Note: There have been reports of risky serotonergic interactions when the two are taken at the same time, but MXE taken to the end of an MDMA experience does not appear to cause the same issues.


cocaine & mxe


Status: Caution


Note: Stimulants taken with MXE can lead to hypermanic states much more easily, especially if sleep is avoided.


caffeine & mxe


Status: Low Risk & No Synergy


Note: No likely interactions


alcohol & mxe


Status: Dangerous


ghb/gbl & mxe


Status: Dangerous


Note: Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the patient falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.


opioids & mxe


Status: Dangerous


Note: This combination can potentiate the effects of the opioid


benzodiazepines & mxe


Status: Caution


Note: Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess.


maois & mxe


Status: Unsafe


Note: MAO-B inhibitors appear to increase the potency of MXE. MAO-A inhbitors have some negative reports associated with the combination but there isn't much information available


ssris & mxe


Status: Caution


amphetamines & dxm


Status: Unsafe


Note: Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.


cocaine & dxm


Status: Unsafe


Note: Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues


caffeine & dxm


Status: Low Risk & No Synergy


Note: High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.


alcohol & dxm


Status: Dangerous


Note: Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Additionally CNS depression can lead to difficulty breathing. Avoid on anything higher than 1st plateau.


ghb/gbl & dxm


Status: Dangerous


Note: Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the patient falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. This combination is hard to predict


opioids & dxm


Status: Dangerous


Note: CNS depression, difficult breathing, heart issues, hepatoxic, just very unsafe combination all around. Additionally if one takes dxm, their tolerance of opiates goes down slightly, thus causing additional synergistic effects.


benzodiazepines & dxm


Status: Caution


Note: Small doses of benzos can end a bad trip, but both substances potentiate the ataxia and sedation caused by the other and this can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position.


maois & dxm


Status: Dangerous


ssris & dxm


Status: Dangerous


amphetamines & pcp


Status: Unsafe


Note: This combination can easily lead to hypermanic states


Status: Unsafe


Note: This combination can easily lead to hypermanic states


cocaine & pcp


Status: Unsafe


Note: This combination can easily lead to hypermanic states


caffeine & pcp


Status: Caution


Note: Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.


alcohol & pcp


Status: Unsafe


Note: Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.


ghb/gbl & pcp


Status: Dangerous


Note: Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.


opioids & pcp


Status: Caution


Note: PCP can reduce opioid tolerance, increasing the risk of overdose


benzodiazepines & pcp


Status: Unsafe


Note: Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely


maois & pcp


Status: Dangerous


Note: This combination is very poorly explored


ssris & pcp


Status: Unsafe


Note: Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.


alcohol & nitrous


Status: Caution


Note: Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.


ghb/gbl & nitrous


Status: Caution


Note: Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.


opioids & nitrous


Status: Caution


Note: Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.


tramadol & nitrous


Status: Caution


Note: Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.


mdma & amphetamines


Status: Low Risk & Synergy


Note: Amphetamines increase the neurotoxic effects of MDMA


cocaine & amphetamines


Status: Caution


Note: This combination of stimulants will increase strain on the heart. It is not generally worth it as cocaine has a mild blocking effect on dopamine releasers like amphetamine


caffeine & amphetamines


Status: Caution


Note: This combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater physical discomfort.


alcohol & amphetamines


Status: Caution


Note: Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel the alcohol and the stimulant less. Extended release formulations may severely impede sleep, further worsening the hangover.


ghb/gbl & amphetamines


Status: Caution


Note: Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.


opioids & amphetamines


Status: Caution


Note: Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.


tramadol & amphetamines


Status: Dangerous


Note: Tramadol and stimulants both increase the risk of seizures.


benzodiazepines & amphetamines


Status: Low Risk & Decrease


Note: Both can dull each other's effects, so if one wears off before the other it's possible to overdose due to the lack of counteraction


maois & amphetamines


Status: Dangerous


Note: MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAO-A inhibitors with amphetamine can lead to hypertensive crises.


cocaine & mdma


Status: Caution


Note: Cocaine blocks some of the desirable effects of MDMA while increasing the risk of heart attack.


caffeine & mdma


Status: Caution


Note: Caffiene is not really necessary with MDMA and increases any neurotoxic effects from MDMA


alcohol & mdma


Status: Caution


Note: Both MDMA and alcohol cause dehydration. Approach this combination with caution, moderation and sufficient hydration. More than a small amount of alcohol will dull the euphoria of MDMA


Status: Caution


Note: Large amounts of GHB/GBL may overwhelm the effects of MDMA on the comedown.


tramadol & mdma


Status: Dangerous


Note: Tramadol and stimulants both increase the risk of seizures.


Status: Dangerous


Note: MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAO-A inhibitors with MDMA will lead to hypertensive crises.


caffeine & cocaine


Status: Caution


Note: Both stimulants, risk of tachycardia, hypertension, and in extreme cases heart failure.


alcohol & cocaine


Status: Unsafe


Note: Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel the alcohol less. Cocaine is potentiated somewhat by alcohol because of the formation of cocaethylene.


ghb/gbl & cocaine


Status: Caution


Note: Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest. Likewise the G can wear off and leave a dangerous concentration of cocaine behind


opioids & cocaine


Status: Dangerous


Note: Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.


tramadol & cocaine


Status: Dangerous


Note: Tramadol and stimulants both increase the risk of seizures.


maois & cocaine


Status: Dangerous


Note: This combination is poorly explored


ssris & cocaine


Status: Low Risk & No Synergy


Note: May reduce each others' effectiveness. Cocaine can reduce mental stability and therefore exacerbate conditions which SSRIs are used to treat.


ghb/gbl & alcohol


Status: Dangerous


Note: Even in very low doses this combination rapidly leads to memory loss, severe ataxia and unconsciousness. There is a high risk of vomit aspiration while unconscious.


opioids & alcohol


Status: Dangerous


Note: Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely


tramadol & alcohol


Status: Dangerous


Note: Heavy CNS depressants, risk of seizures. Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely.


benzodiazepines & alcohol


Status: Dangerous


Note: Ethanol ingestion may potentiate the CNS effects of many benzodiazepines. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Blacking out and memory loss is almost certain.


maois & alcohol


Status: Unsafe


Note: Tyramine found in many alcoholic beverages can have dangerous reactions with MAOIs, causing an increase in blood pressure.


ssris & alcohol


Status: Caution


Note: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.


opioids & ghb/gbl


Status: Dangerous


Note: The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position


tramadol & ghb/gbl


Status: Dangerous


Note: The sedative effects of this combination can lead to dangerous respiratory depression.


benzodiazepines & ghb/gbl


Status: Dangerous


Note: The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position.


tramadol & opioids


Status: Dangerous


Note: Concomitant use of tramadol increases the seizure risk in patients taking other opioids. These agents are often individually epileptogenic and may have additive effects on seizure threshold during coadministration. Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present


benzodiazepines & opioids


Status: Dangerous


Note: Central nervous system and/or respiratory-depressant effects may be additively or synergistically present. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position Blackouts/memory loss likely


maois & opioids


Status: Caution


Note: Coadministration of monoamine oxidase inhibitors (MAOIs) with certain opioids has been associated with rare reports of severe and fatal adverse reactions. There appear to be two types of interaction, an excitatory and a depressive one. Symptoms of the excitatory reaction may include agitation, headache, diaphoresis, hyperpyrexia, flushing, shivering, myoclonus, rigidity, tremor, diarrhea, hypertension, tachycardia, seizures, and coma. Death has occurred in some cases.


ssris & opioids


Status: Low Risk & No Synergy


Note: There have been very infrequent reports of a risk of serotonin syndrome with this combination, though this should not be a practical concern.


benzodiazepines & tramadol


Status: Dangerous


Note: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present. Vomit aspiration a risk when passed out, lay down in recovery position if ingested.


LSD & 5-MeO-xxT


\"Low doses antagonized the effects of both hallucinogens, whereas larger doses enhanced their effects.\"


DMT & 5-MeO-xxT


The 5-MeO class of tryptamines can be unpredictable in their interactions.


The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops.


The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops.


High doses of caffeine are uncomfortable and this will be magnified by psychedelics.


This combination can cause seizures due to the lowering of the threshold by tramadol and the potential of mescaline to cause seziures.


DOx & 5-MeO-xxT


The 5-MeO class of tryptamines can be unpredictable in their interactions, particularly increasing the risk of unpleasant physical side effects.


Ketamine and psychedelics tend to potentiate each other - go slowly.


The DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also potentiate DOx resulting in an unpleasantly intense experience.


The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenic.


The combined stimulating effects of the two can be uncomfortable. Coming down on the MDMA while the DOx is still active can be quite anxiogenic.


The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought loops. Coming down from cocaine while the DOx is still active can be quite anxiogenic.


High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating it may cause some physical discomfort.


Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk.


No unexpected interactions.


Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.


The 5-MeO class of tryptamines can be unpredictable in their interactions and the NBOMes are known to be unpredictable even alone. This combination is best avoided.


Amphetamines and NBOMes both provide considerable stimulation. When combined they can result in tachycardia, hypertension, vasoconstriction and in extreme cases heart failure. The anxiogenic and focusing effects of stimulants are also not good in combination with psychedelics as they can lead to unpleasant thought loops. NBOMes are known to cause seizures and stimulants can increase this risk.


Caffiene can bring out the natural stimulation from psychedelic drugs to make it uncomfortable. High doses can cause anxiety which is hard to handle while tripping.


2C-x & 5-MeO-xxT


The 5-MeO psychedelics can interact unpredictably to potentiate other psychedelics.


The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally uneccessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.


The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.


High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.


Tramadol is well known to lower seizure threshold and psychedelics raise the risk of seizures.


2C-T-x & 5-MeO-xxT


High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.


Both these classes of compound can interact unpredictably. Caution should be exercised.


No expected interactions, some Opioids have Serotonin action, and could lead to Serotonin Syndrome or a seizure. These are pretty much only to Pentazocine, Methadone, Tramadol, Tapenatdol.


2C-T-x & SSRIs


αMT & 5-MeO-xxT


High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.


αMT has a broad mechanism of action in the brain and so does alcohol so the combination can be unpredictable.


No unexpected interactions


5-MeO-xxT & DXM


The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.


5-MeO-xxT & MDMA


Some of the 5-MeO tryptamines are a bit unpredictable and should be mixed with MDMA with care.


The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.


No unexpected interactions.


Both substances cause ataxia and bring a very high risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.


Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.


Both substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.


No unexpected interactions.


Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position.


Risk of tachycardia, hypertension, and manic states.


There have been reports of risky serotonergic interactions when the two are taken at the same time, but MXE taken to the end of an MDMA experience does not appear to cause the same issues.


No likely interactions.


Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the patient falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.


This combination can potentiate the effects of the opioid.


Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess.


Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.


Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.


High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.


Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Additionally CNS depression can lead to difficulty breathing. Avoid on anything higher than 1st plateau.


Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the patient falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. This combination is hard to predict.


CNS depression, difficult breathing, heart issues, hepatoxic, just very unsafe combination all around. Additionally, there is a reverse cross tolerance between opiates/dxm. I.E. if one takes dxm, their tolerance of opiates goes down slightly, thus causing additional synergistic effects.


Small doses of benzos can end a bad trip, but both substances potentiate the ataxia and sedation caused by the other and this can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position.


This combination can lead to vomiting.


Amphetamines increase the neurotoxic effects of MDMA.


This combination of stimulants will increase strain on the heart. It is not generally worth it as cocaine has a mild blocking effect on dopamine releasers like amphetamine.


This combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater physical discomfort.


Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel the alcohol and the stimulant less. Extended release formulations may severely impede sleep, further worsening the hangover.


Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.


Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.


Tramadol and stimulants both increase the risk of seizures.


Cocaine blocks some of the desirable effects of MDMA while increasing the risk of heart attack.


Caffiene is not really necessary with MDMA and increases any neurotoxic effects from MDMA.


Both MDMA and alcohol cause severe dehydration. Approach this combination with caution, moderation and sufficient hydration.


Tramadol and stimulants both increase the risk of seizures.


Both stimulants, risk of tachycardia, hypertension, and in extreme cases heart failure.


Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel he alcohol less. Cocaine is potentiated somewhat by alcohol because of the formation of cocaethylene.


Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest. Likewise the G can wear off and leave a dangerous concentration of cocaine behind.


Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.


Tramadol and stimulants both increase the risk of seizures.


Even in very low doses this combination rapidly leads to memory loss, severe ataxia and unconsciousness. There is a high risk of vomit aspiration while unconscious.


Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely.


Heavy CNS depressants, risk of seizures. Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely.


Ethanol ingestion may potentiate the CNS effects of many benzodiazepines. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Blacking out and memory loss is almost certain.


The chemical tyramine in alcoholic beverages can have dangerous reactions with MAOIs, causing an increase in blood pressure.


Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.


The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position.


The sedative effects of this combination can lead to dangerous respiratory depression.


The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position.


Concomitant use of tramadol increases the seizure risk in patients taking other opioids. These agents are often individually epileptogenic and may have additive effects on seizure threshold during coadministration. Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present.


Central nervous system and/or respiratory-depressant effects may be additively or synergistically present. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position Blackouts/memory loss likely.


Coadministration of monoamine oxidase inhibitors (MAOIs) with certain opioids has been associated with rare reports of severe and fatal adverse reactions. There appear to be two types of interaction, an excitatory and a depressive one. Symptoms of the excitatory reaction may include agitation, headache, diaphoresis, hyperpyrexia, flushing, shivering, myoclonus, rigidity, tremor, diarrhea, hypertension, tachycardia, seizures, and coma. Death has occurred in some cases.


Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present. Vomit aspiration a risk when passed out, lay down in recovery position if ingested


Original article and pictures take http://wiki.tripsit.me/wiki/Drug_combinations site

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